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Iodine mediated synthesis of some new imidazo[1,2‐a]pyridine derivatives and evaluation of their antimicrobial activity
Author(s) -
Ashok Dongamanti,
Ram Reddy M.,
Ramakrishna Katta,
Nagaraju Nalaparaju,
Dharavath Ravinder,
Sarasija Madderla
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3967
Subject(s) - chemistry , antimicrobial , iodine , nystatin , proton nmr , pyridine , antifungal , elemental analysis , aryl , carbon 13 nmr , stereochemistry , antibacterial activity , streptomycin , combinatorial chemistry , organic chemistry , medicinal chemistry , bacteria , antibiotics , microbiology and biotechnology , biochemistry , alkyl , biology , genetics
Herein, we reported a series of new 2‐(5‐methyl‐1‐aryl‐1H‐1,2,3‐triazol‐4‐yl)imidazo[1,2‐a]pyridines by using iodine and NH 4 OAc in good yields. The structures of the titled compounds were characterized by the elemental analysis, 1 H NMR, 13 C NMR, IR, and mass spectral analysis. All the titled compounds were screened for their in vitro antibacterial and antifungal activities by using streptomycin and Nystatin as standard drugs. The compounds 3k , 3l , 3g , and 3c exhibited potent activity against the tested bacterial strains and 3k , 3l , and 3c exhibited potent activity against the tested fungal strains than the reference drugs.