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Synthesis of some oxazolo and oxazinopyrano[3,2‐ c ]quinolines and their antitumor activity
Author(s) -
AbdelKader Dalia,
Abass Mohamed
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3963
Subject(s) - chemistry , quinoline , electrophile , stereochemistry , nitro , derivative (finance) , combinatorial chemistry , organic chemistry , catalysis , alkyl , financial economics , economics
3‐Amino‐4‐hydroxy‐6‐phenylpyrano[3,2‐ c ]quinoline‐2,5(6 H )‐dione was produced by a smooth reduction of its nitro precursor. Reaction of this 3‐amino‐4‐hydroxypyranoquinoline derivative with different electrophiles, leading to a variety of oxazolo and oxazinopyrano[3,2‐ c ]quinoline derivatives, was described. The structure of the new products was elucidated via elemental analysis, IR, 1 H NMR, 13 C NMR, and mass spectra. Also, screening the antitumor activity of new compounds against two human cell lines (HepG‐2 and HCT‐116) was carried out. Some new products showed significant antitumor activities.