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A quick and regioselective access of spirooxindole‐oxazoline by reaction of isatin and isocyanoacetate “on water”
Author(s) -
Rankan Chandran,
Santhi Marimuthu Prabhakaran,
Tiwari Keshri Nath
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3953
Subject(s) - isatin , regioselectivity , chemistry , oxazoline , yield (engineering) , combinatorial chemistry , substrate (aquarium) , organic chemistry , catalysis , materials science , oceanography , metallurgy , geology
A greener, rapid and regioselective “on water” synthesis of spirooxindole‐oxazoline by the reaction of isatin and isocyanoacetate at room temperature is described. The developed protocol has the advantage of being atom‐economical, eco‐friendly, and benign reaction conditions. Broader substrate scope, experimentally simple procedures, and easy purification of products with high yield further make this method attractive. The synthesized compounds have been fully characterized with spectral analysis.