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Design, synthesis of tri‐substituted pyrazole derivatives as promising antimicrobial agents and investigation of structure activity relationships
Author(s) -
Reddy Guda Mallikarjuna,
Garcia Jarem Raul,
Yuvaraja Gutha,
Venkata Subbaiah Munagapati,
Wen JetChau
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3952
Subject(s) - antimicrobial , chemistry , bacteria , pyrazole , combinatorial chemistry , antibiotics , biological activity , structure–activity relationship , drug , pharmacology , organic chemistry , biochemistry , in vitro , biology , genetics
The major diseases spread in the environment only because of microbes. Even, intensive care units in the hospitals are polluted by microorganisms, particularly, Gram‐positive bacteria. Although many antibiotics are existed, there is a need to develop up to date microbial‐resistant agents. Hence, the current study aimed to develop prominent antimicrobial drug‐related compounds. Thus, a novel series of tri‐substituted analogs and their intermediates were synthesized. In addition, total new compounds were screened for their antimicrobial assay and identified as the most efficient biologically active compounds. Moreover, minimal inhibitory antimicrobial activity and appropriate structure activity relationships were investigated. From the results it was observed that, viability of Gram‐positive bacteria was most powerfully affected by all active compounds. Finally, this research demonstrated that, these biologically energetic amalgams can be utilized for further preclinical studies with the ambition of standing unique inventive drugs.