Synthesis of isomeric 2,3,5‐trisubstituted perhydropyrrolo[3,4‐d]‐isoxazole‐4,6‐diones via 1,3‐dipolar cycloaddition reactions

A series of isoxazolidine derivates (isomeric 2,3,5‐trisubstitutedperhydropyrrolo[3,4‐d]isoxazole‐4,6‐diones) used as anti‐inflammatory, immunosuppressive, antibacterial agent, and inhibitor for some enzymes were synthesized. These compounds were prepared by 1,3‐dipolar cycloaddition of N ‐methyl maleimide and N ‐phenyl maleimide with nitrones. Diastereomeric products obtained in this reaction were separated by column chromatography and recrystallized. All compounds synthesized were characterized by elemental analysis and spectroscopic methods ( 1 H NMR, 13 C NMR, and FTIR). J. Heterocyclic Chem., (2010).