One‐pot synthesis of novel polysubstituted furopyran derivatives via pseudo seven‐component reaction (6 + 1) of isocyanides with bisarylidene Meldrum's acid containing ether groups

In the present study, a group of polysubstituted furopyran derivatives possessing ether spacer groups were synthesized under good‐to‐exceptional yields via cycloaddition of bisarylidene Meldrum's acid derivatives (1 mmol) with isocyanides (6 mmol) within dichloromethane (CH 2 Cl 2 ) for 3 to6 hours at room temperature with no assistance from any type of catalysts. The structure of the products was then confirmed by Fourier Transform‐infrared spectroscopy, 1 H‐nuclear magnetic resonance spectroscopy, 13 C‐nuclear magnetic resonance spectroscopy, and elemental analysis. Moreover, the 5c , 5d , and 5f compounds exhibited favorable pharmaceutical behavior as antibacterial.