Premium
Synthesis of chromenone, pyrimidinone, thiazoline, and quinolone derivatives as prospective antitumor agents
Author(s) -
ElHelw Eman A. E.,
ElBadawy Azza A.
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3948
Subject(s) - chemistry , thiazoline , hydrazone , hydrazide , pyrazole , reagent , nitrile , methylene , hydrazine (antidepressant) , aldehyde , in vitro , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , catalysis
Hydrazide‐hydrazone namely, 2‐cyano‐ N ′‐((1‐phenyl‐3‐[thiophen‐2‐yl]‐1 H ‐pyrazol‐4‐yl)methylene)acetohydrazide (3) underwent a series of reactions with some chemical reagents to construct new biologically active N ‐heterocycles, for example, chromenone, benzochromenone, thiazoline, and quinolone derivatives. Treating the nitrile derivative 3 with 2,4‐dichlorobenzaldehyde and pyrazole aldehyde 1 afforded the corresponding condensed products. Some of the synthesized compounds were screened for their in vitro antitumor activities against two different human tumor cell lines including hepatocellular liver carcinoma (HepG2) and breast adenocarcinoma (MCF7) activities. Compound 3 was the most potent against the two tumors.