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Synthesis of novel bis‐ and poly(benzimidazoles) as well as bis‐ and poly(benzothiazoles) as anticancer agents
Author(s) -
Hebishy Ali M. S.,
Abdelfattah Mohamed S.,
Elmorsy Abdullah,
Elwahy Ahmed H. M.
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3947
Subject(s) - chemistry , benzothiazole , cell culture , combinatorial chemistry , ethanol , human breast , cancer cell lines , biochemistry , cancer cell , cancer , medicine , genetics , biology
A synthesis of bis‐ and poly(benzimidazoles) as well as bis‐ and poly(benzothiazoles) was attempted using different protocols. The best results were obtained by employing the reaction of the appropriate bis‐ or poly(aldehydes) with o ‐phenylenediamine or 2‐aminothiophenol, respectively, in ethanol at reflux in the presence of NaHSO 3 . The anticancer activities of the synthesized compounds were evaluated against human breast adenocarcinoma cell line (MCF‐7), liver cancer cell line (HepG‐2), and epithelial colorectal adenocarcinoma cells (CaCO‐2). Hexakis(benzothiazole) was found to exhibit the highest activity against HepG‐2 and MCF‐7 cell lines with IC 50 values of 21.16 and 13.25 μM, respectively.