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Design, synthesis, and characterization of some new benzimidazole derivatives and biological evaluation
Author(s) -
Bektaş Hakan,
Sökmen Bahar B.,
Aydın Sinem,
Menteşe Emre,
Bektaş Adile,
Dilekçi Gamze
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3943
Subject(s) - benzimidazole , chemistry , antimicrobial , enterobacter aerogenes , proton nmr , oxadiazole , antioxidant , carbon 13 nmr , 1,2,4 triazole , organic chemistry , combinatorial chemistry , stereochemistry , nuclear chemistry , biochemistry , escherichia coli , gene
A new series of benzimidazole derivatives ( 1‐15 ) containing 1,2,4‐triazole, 1,3,4‐thiadiazole, 1,3,4‐oxadiazole, and thiazolidinon rings have been synthesized. All new synthesized benzimidazole compounds were confirmed by 1 H NMR, 13 C NMR spectra, and LC‐MS, and they were examined for their antioxidant and antimicrobial activities. Compounds 7 and 1 showed the highest and the lowest antioxidant activities, respectively. The lowest minimum inhibition concentration value found in compound 5 against Enterobacter aerogenes .