Premium
A Cascade synthesis of 11 bH ‐Imidazo[1,2‐ c ]isoquinolino[2,1‐ a ]quinazoline derivatives catalyzed by AgOTf
Author(s) -
Wu Hao,
Wang YiChun,
Li TuanJie,
Liu JianQuan,
Wang XiangShan
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3940
Subject(s) - chemistry , hydroamination , aniline , catalysis , quinazoline , domino , cascade reaction , cascade , medicinal chemistry , condensation , combinatorial chemistry , organic chemistry , physics , chromatography , thermodynamics
A cascade reaction of 2‐alkynylbenzaldehydes and 2‐(4,5‐diphenyl‐1 H ‐imidazol‐2‐yl)aniline was treated in DMF catalyzed by AgOTf leading to 6,13,14‐triaryl‐11 bH ‐imidazo[1,2‐ c ] isoquinolino[2,1‐ a ]quinazolines in high yields. This Domino reaction included condensation, cyclization, and acetylenic hydroamination under mild conditions to build fused pentacyclic heterocycle with three new bonds and two new rings.