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Multicomponent reactions and supramolecular catalyst: A perfect synergy for eco‐compatible synthesis of pyrido[2,3‐ d ]pyrimidines in water
Author(s) -
Chate Asha V.,
Kulkarni Ankita S.,
Jadhav Chetan K.,
Nipte Amol S.,
Bondle Girabala M.
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3938
Subject(s) - chemistry , catalysis , pyrimidine , solvent , combinatorial chemistry , cyclodextrin , supramolecular chemistry , reaction conditions , process (computing) , organic chemistry , molecule , stereochemistry , computer science , operating system
Abstract In this article, we have developed a straightforward, easy and exceedingly competent approach for the synthesis of 5‐phenyl‐5,6‐dihydropyrido[2,3‐ d ]pyrimidine‐2,4,7(1 H ,3 H ,8 H )‐triones obtain in superior yields in a sole reaction pace with an air and humidity steady catalyst in water as a green solvent at 100 ° C. The present procedure paves the approach for the synthesis of biologically fascinating molecular frameworks and has reward in conditions of little catalyst loading with palpable ambiguous and straightforward‐to‐do reaction circumstances with easy purification process. The used β‐cyclodextrin catalyst was recuperated and repeated several times devoid of noteworthy loss of catalytic activity, which is a crucial parameter of green synthesis.