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Application of metal free aromatization to total synthesis of perlolyrin, flazin, eudistomin U and harmane
Author(s) -
Santhanam Srinath,
Ramu Abinaya,
Baburaj Baskar,
Kalpatu Kuppusamy Balasubramanian
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3931
Subject(s) - chemistry , aromatization , total synthesis , alkyl , stereochemistry , organic chemistry , combinatorial chemistry , catalysis
Application of our recently reported metal free reaction conditions to the total synthesis of the four different and selective biologically interesting β‐carboline natural products is reported. Using this simple methodology, flazin, perlolyrine, eudistomin U and harmane containing heteroaryl and alkyl substituents at C1 position were synthesized in good yields.