Premium
Efficient reactions for the synthesis of pyrazolo[3,4‐ b ]pyridine and pyrano[2,3‐ c ]pyrazole derivatives from N ‐methyl‐1‐(methylthio)‐2‐nitroethen‐1‐amine
Author(s) -
Ji Yifan,
Li Li,
Zhu Guangzhou,
Zhou Ya,
Lu Xinchi,
He Wenjing,
Gao Lijiu,
Rong Liangce
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3903
Subject(s) - chemistry , pyrazole , pyridine , amine gas treating , combinatorial chemistry , medicinal chemistry , organic chemistry , stereochemistry
The efficient and novel method for the synthesis of pyrazolo[3,4‐ b ]pyridine and pyrano[2,3‐ c ]pyrazole derivatives from the multicomponent reaction of aromatic aldehydes (isatins), N ‐methyl‐1‐(methylthio)‐2‐nitroethen‐1‐amine, and 3‐aminopyrazole or methyl 3‐hydroxy‐1 H ‐pyrazole‐5‐carboxylate under normal laboratory conditions was reported in this research. The advantages of this research are wide range of substrates, high yields, and simple operation.