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Green synthetic investigation and spectral characterization of some spiro pyrazolidine‐based heterocycles with potential biological activity
Author(s) -
ElOssaily Yasser A.,
Metwally Saoud A.,
AlMuailkel Nayef S.,
Fawzy Ahmed,
Ali Hazim M.,
Naffea Yousra A.
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3898
Subject(s) - chemistry , chalcone , malonic acid , hydrazine (antidepressant) , elemental analysis , organic chemistry , solvent , spectral analysis , spectral properties , reaction conditions , combinatorial chemistry , catalysis , computational chemistry , chromatography , spectroscopy , physics , quantum mechanics
A green, rapid, and efficient methodology is developed for the synthesis of 1‐phenyl‐3,5‐pyrazolidinedione ( 3 ) by the reaction of malonic acid with phenyl hydrazine in the presence of phosphorous oxychloride under solvent‐free conditions. The later compound 3 was used as a versatile precursor for green synthesis of chalcone derivatives ( 4a‐h ) and spiroheterocyclic compounds ( 5a‐h ) with good to excellent isolated yields. The chemical structures of the synthesized compounds were elucidated on the basis of elemental and spectral analyses.