Premium
ZnO nanorods as efficient catalyst for the green synthesis of thiophene derivatives: Investigation of antioxidant and antimicrobial activity
Author(s) -
Hamedani Naghmeh Faal,
Ghazvini Maryam,
SheikholeslamiFarahani Fatemeh,
BagherianJamnani Mohammad Taghi
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3884
Subject(s) - chemistry , butylated hydroxytoluene , catalysis , antimicrobial , thiophene , antioxidant , alkyl , organic chemistry , dpph , ferric , yield (engineering) , nanorod , combinatorial chemistry , nuclear chemistry , nanotechnology , materials science , metallurgy
In this work, thiophene derivatives were synthesized in good yields via multicomponent reaction of isoquinoline, alkyl bromides, activated acetylenic compounds, isothiocyanates, and catalytic amounts of ZnO nanorods (NRs) at room temperature under solvent‐free conditions. This procedure for the synthesis of thiophene derivatives is green, easy, and simple with excellent yield. In addition, DPPH radical scavenging and ferric reduction power experiment has been studied for the evaluation of the antioxidant activity of some prepared thiophenes, for example, 5b , 5d , 5e , and 5f . As outcome, the compound 5d exhibited a noteworthy radical trapping activity and excellent reducing ability than synthetic antioxidants such as butylated hydroxytoluene (BHT) and 2‐tertbutylhydroquinone (TBHQ). Moreover, the antimicrobial activity of some synthesized thiophenes was confirmed by employing the disk diffusion test on Gram‐positive and Gram‐negative bacteria. The obtained results of disk diffusion test showed that compounds 5b , 5d , 5e , and 5f prevented bacterial growth.