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Design and synthesis of diethyl(substituted 2‐benzylbenzofuran‐3‐yl)phosphonates as antioxidant and antimicrobial agents
Author(s) -
Gundluru Mohan,
Sarva Santhisudha,
Sudileti Murali,
Tellamekala Sreekanth,
Yakkate Subba Rao,
Nemallapudi Bakthavatchala Reddy,
Cirandur Suresh Reddy
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3877
Subject(s) - chemistry , antimicrobial , phosphonate , catalysis , dpph , acetylene , ethanol , antioxidant , organic chemistry , bacteria , combinatorial chemistry , genetics , biology
In continuance of our effort to improve novel and potent synthetic approaches for various bioactive phosphorylated heterocycles via C─P bond formation, a series of diethyl substituted(2‐benzylbenzofuran‐3‐yl)phosphonate derivatives ( 4a ‐ j ) was synthesized by one‐pot reaction of various diversely substituted salicylaldehydes, phenyl acetylene, and diethyl phosphite using CuO nanoparticles as catalyst in 1:1 ethanol and water under room temperature. The new compounds have been studied for their radical scavenging activity by DPPH, H 2 O 2 , and NO approaches and antimicrobial activity assay against bacteria and fungi by disk diffusion method.