Premium
One‐pot multi‐component synthesis of novel ethyl‐2‐(3‐((2‐(4‐(4‐aryl)thiazol‐2‐yl)hydrazono)methyl)‐4‐hydroxy/isobutoxyphenyl)‐4‐methylthiazole‐5‐carboxylate derivatives and evaluation of their in vitro antimicrobial activity
Author(s) -
Deshineni Rajitha,
Velpula Ravibabu,
Koppu Suneetha,
Pilli Jyothi,
Chellamella Gyanakumari
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3872
Subject(s) - chemistry , phenacyl , carboxylate , ethanol , acetic acid , carbon 13 nmr , medicinal chemistry , aryl , proton nmr , stereochemistry , organic chemistry , alkyl
A novel series of ethyl‐2‐(3‐((2‐(4‐(4‐aryl)thiazol‐2‐yl)hydrazono)methyl)‐4‐hydroxy/isobutoxyphenyl)‐4‐methylthiazole‐5‐carboxylate derivatives ( 4a‐f and 5a‐f ) were synthesized by employing one‐pot multi‐component approach involving ethyl 2‐(3‐formyl‐4‐oxy/isobutoxyphenyl)‐4‐methylthiazole‐5‐carboxylate, thiosemicarbazide and various phenacyl bromides/3‐(2‐bromoacetyl)‐2 H ‐chromen‐2‐one/2‐(2‐bromoacetyl)‐3 H ‐benzo[ f ]chromen‐3‐onein ethanol in the presence of catalytic amount of acetic acid. The structures of all the synthesized compounds were confirmed with spectral analysis, ie, IR, 1H NMR, 13C NMR and mass spectrometry, and all the compounds were screened for their in vitro antimicrobial activity.