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NIS‐promoted multicomponent reaction of 2‐aminopyridines with aldehydes and nitromethane for the synthesis of 3‐nitroimidazo[1.2‐ a ]pyridines
Author(s) -
Sun Jinwei,
Yang Xinrui,
Liu Yun,
Wang Yi,
Pan Yi
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3869
Subject(s) - chemistry , aminopyridines , nitromethane , substituent , combinatorial chemistry , reaction conditions , organic chemistry , catalysis
An efficient synthesis of 3‐nitroimidazo[1,2‐ a ]pyridines has been developed via N ‐iodosuccinimide (NIS)‐mediated multicomponents reaction of 2‐aminopyridines, aldehydes, and nitromethane under metal‐free conditions. This protocol has many advantages such as broad substituent scope, mild and eco‐friendly conditions, high step economy, and good yields.