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Tandem heterocyclization of 2‐(azolyl‐(azinyl‐))anilines as an efficient method for preparation of substituted pyrrolo[1,2‐ a ]azolo‐(azino‐)[ c ]quinazolines
Author(s) -
Stavytskyi Viktor,
Voskoboinik Oleksii,
Antypenko Oleksii,
Krasovska Nataliia,
Shabelnyk Konstantyn,
Konovalova Iryna,
Shishkyna Svitlana,
Kholodniak Sergiy,
Kovalenko Serhii
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3862
Subject(s) - chemistry , tandem , combinatorial chemistry , proton nmr , medicinal chemistry , stereochemistry , composite material , materials science
The synthesis of novel pyrrolo[1,2‐ a ]azolo‐(azino‐)[ c ]quinazolines by tandem reaction of 2‐(azolyl‐(azinyl‐))anilines with oxocarboxylic acids was described in this article. The mechanism of obtained compounds formation was proposed, and the intermediate of the heterocyclization has been isolated and characterized. The IR‐, 1 H and 13 C NMR‐, chromato‐mass spectra of synthesized compounds were studied for estimation of their structure and spectral patterns features. The molecular structure of the obtained compounds was additionally proved by X‐ray diffraction method.