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Antitumor, cytotoxic, and antioxidant evaluation of six heterocyclic compounds containing different heterocycle moieties
Author(s) -
Radwan Tasneem Mokhtar,
ElHashash Maher AbdelAziz,
Wasfy Ashraf AbdelHamid Farouk,
Abdallah Suzan Abdelhalim
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3847
Subject(s) - hela , sulforhodamine b , chemistry , quinazolinone , cell culture , in vitro , cytotoxicity , cytotoxic t cell , antioxidant , bromide , benzimidazole , stereochemistry , biochemistry , combinatorial chemistry , organic chemistry , biology , genetics
Heterocyclic compounds with different heterocycle moieties, namely benzoxazinone, benzimidazole, quinazolinone, and benzofuranone heterocyclic rings, were synthesized, characterized, and evaluated for their anticancer activity against human hepatocellular carcinoma cell line (HepG2) using sulforhodamine B (SRB) and dimethylthiazol‐diphenyltetrazolium bromide (MTT) assays. Also, their cytotoxic activities were tested against human epithelioid carcinoma (Hela) cell line in comparison with normal cell, amniotic epithelial (WISH) cell line, as an in vitro toxicity estimation model. The results showed clearly that 2‐(2‐benzyl‐4‐oxoquinazolin‐3(4 H )‐yl)acetohydrazide 4 is the most potent antioxidant and anticancer agents. Although, 3‐amino‐2‐benzylquinazolin‐4(3 H )‐one 5 is less potent anticancer agent against Hela but it is more safe against normal cell (WISH).