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Synthesis of 5‐amino‐1,3,4‐thiadiazoles containing dithiocarbamate groups
Author(s) -
Khoshdoun Maryam,
Taheri Salman,
Daneshgar Parandis,
Jamshidi Hamid R.,
Ziyaei Halimehjani Azim
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3841
Subject(s) - chemistry , dithiocarbamate , ethanol , alkyl , solvent , column chromatography , thiadiazoles , glycine , organic chemistry , chromatography , amino acid , biochemistry
Synthesis of alkyl ((5‐[alkylamino]‐1,3,4‐thiadiazol‐2‐yl)methyl)carbamodithioates via the reaction of glycine‐based dithiocarbamates with thiosemicarbazides in the presence of POCl 3 in ethanol is disclosed. The main advantages of this method including the use of ethanol as solvent, no need to column chromatography for purification and high to excellent yields of products are noteworthy.