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Synthesis of novel tricyclic 4‐chloro‐7,8,10,11‐tetrahydro‐5 H ‐benzo[ e ]pyrimido[4,5‐ b ][1,4]diazepin‐9(6 H )‐ones
Author(s) -
Xiang Jinbao,
Zheng Lianyou,
Zhu Tong,
Dang Qun,
Bai Xu
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.384
Subject(s) - chemistry , tricyclic , iminium , stereochemistry , medicinal chemistry , organic chemistry , catalysis
AbstractA series of tricyclic 7,8,10,11‐tetrahydro‐5 H ‐benzo[ e ]pyrimido[4,5‐ b ][1,4]diazepin‐9(6 H )‐ones were prepared in moderate to high yields using TFA‐promoted iminium‐cyclization reactions of 3‐(6‐(butylamino)‐4‐chloropyrimidin‐5‐ylamino)cyclohex‐2‐enones and various aldehydes. J. Heterocyclic Chem., (2010).