Premium
Synthesis of fused hydroxy dihydropyrroles and unexpected dihydropyrazine and dihydroquinoxaline derivatives based on heterocyclic ketene aminals
Author(s) -
Rezaei Monireh,
Bayat Mohammad,
Notash Behrouz
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3834
Subject(s) - chemistry , ketene , phenylglyoxal , catalysis , organic chemistry , combinatorial chemistry , amino acid , biochemistry , arginine
The one‐pot four‐component synthesis of highly functionalized fused hydroxyl dihydropyrroles and dihydropyrazines from readily available diamines, 1,1‐bis (methylsulfanyl)‐2‐nitroethene, phenylglyoxal monohydrates, and C‐H acids have been developed. This strategy provides an efficient, catalyst‐free approach for easy access to various new hydroxyl‐dihydropyrrole and dihydropyrazine rings in good to high yields. The products were confirmed by 1 H and 13 C NMR, IR, mass, and X‐ray crystal structure analyses.