Cascade CN and CO bond constructions for the synthesis of dibenzoimidazo[1,4]oxazepines catalyzed by CuI/ o ‐phen | Zendy

Li ZhuoHuan | Zendy; Li TuanJie | Zendy; Liu JianQuan | Zendy; Wang XiangShan | Zendy

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Cascade CN and CO bond constructions for the synthesis of dibenzoimidazo[1,4]oxazepines catalyzed by CuI/ o ‐phen

Author(s) -

Li ZhuoHuan,

Li TuanJie,

Liu JianQuan,

Wang XiangShan

Publication year - 2020

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.3831

Subject(s) - chemistry , iodobenzene , imidazole , catalysis , substrate (aquarium) , medicinal chemistry , cascade , nucleophile , stereochemistry , double bond , polymer chemistry , organic chemistry , oceanography , chromatography , geology

A novel method for the synthesis of dibenzo[ b , f ]imidazo[1,2‐ d ][1,4]oxazepine derivatives was described via cascade Csp 2 N and Csp 2 O bond constructions. It was a crossed double Ullmann reactions using 4,5‐diaryl‐2‐(2‐hydroxylphenyl)‐1 H ‐imidazole as the double nucleophilic centers in the presence of Cs 2 CO 3 , while 1‐bromo‐2‐iodobenzene was used as a substrate catalyzed by CuI and o ‐phenanthroline in good yields.

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