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Synthesis of Pyrano[2,3‐ d ]pyrimidine‐2,4‐diones and Pyridino[2,3‐ d ]pyrimidine‐2,4,6,8‐tetraones: Evaluation Antitumor Activity
Author(s) -
Haggam Reda A.,
Assy Mohamed G.,
Mohamed Enaiat K.,
Mohamed Abdussattar S.
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3830
Subject(s) - chemistry , barbituric acid , pyrimidine , reagent , nucleophile , hydrazine (antidepressant) , hydrate , medicinal chemistry , organic chemistry , stereochemistry , catalysis , chromatography
Abstract A series of some novel pyrano[2,3‐ d ]pyrimidine 4 – 10 with 75–95% yields and pyridino[2,3‐ d ]pyrimidine derivatives 11 – 16 with 75–92% yields is reported. The building structures have been achieved by reaction of 5‐arylidene barbituric acid 2 and active nucleophile carbon or nitrogen as examples barbituric acid and acetyl acetone or refluxing of bispyrimidine‐2,4,6‐trione derivative 3 with cyclizing reagents such as phosphorous pentoxide, hydrazine hydrate and aminothiazole. The newly synthesized structures have been elucidated on the basis of their spectral analysis. Some selected members were screened for antitumor activity. Among the screened compounds 9 , 16 , 7 , 10 and 8 exhibited high antitumor activity.