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Synthesis and antimicrobial activity of novel 1,3,4‐oxadiazolyl‐quinazolin‐4(3 H )ones
Author(s) -
Patel Navin B.,
Patel Jaymin C.
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.383
Subject(s) - chemistry , antimicrobial , broth microdilution , candida albicans , bacteria , antifungal , antibacterial activity , in vitro , stereochemistry , microbiology and biotechnology , organic chemistry , minimum inhibitory concentration , biochemistry , genetics , biology
A series of 1,3,4‐oxadiazolyl‐quinazolin‐4(3 H )ones have been synthesized using known methods. All the compounds have been established on basis of elemental analysis, IR and NMR spectral data. The in vitro antimicrobial screening of the synthesized compounds were carried out against two gram‐positive bacteria ( S. aureus , S. pyogenes ), two gram‐negative bacteria ( E. coli , P. aeruginosa ), and three fungal species ( C. albicans , A. niger , A. clavatus ) using the broth microdilution method. The compounds 7d , 7g , 7l , 7o , 7p , and 7r possessed pronounced antibacterial activity whereas compound 7p exhibited promising antifungal activity. J. Heterocyclic Chem., (2010).