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Synthesis, characterization, and antioxidant and anticholinesterase activities of pyrazolo derivatives
Author(s) -
Sicak Yusuf,
OruçEmre Emine E.,
Öztürk Mehmet,
Karaküçükİyidoğan Ayşegül,
Nadeem Said
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3829
Subject(s) - chemistry , morpholine , antioxidant , elemental analysis , galantamine , ring (chemistry) , proton nmr , nuclear chemistry , organic chemistry , stereochemistry , donepezil , medicine , dementia , disease , pathology
Twenty‐four pyrazolo derivatives (1–4)(a‐f) were synthesized and characterized by FTIR, 1 H, and 13 C NMR (Nuclear Magnetic Resonance), and elemental analysis. The synthesized compounds were also investigated for their antioxidant and anticholinesterase activities. The compounds (3–4)(a‐f) carrying morpholine ring were more active than the piperidinyl containing compounds (1–2)(a‐f) in both activities. The compound 4f showed higher activity in both assays as compared with the others. Additionally, the anticholinesterase activity test provided higher values than the galantamine in the BChE assay. Therefore, compound 4f can be used as anticholinesterase agent and/or anticholinesterase assay standard.