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β‐Cyclodextrin catalyzed access to fused 1,8‐dihydroimidazo[2,3‐ b ]indoles via one‐pot multicomponent cascade in aqueous ethanol: Supramolecular approach toward sustainability
Author(s) -
Nipate Amol S.,
Jadhav Chetan K.,
Chate Asha V.,
Taur Kanchan S.,
Gill Charansingh H.
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3828
Subject(s) - chemistry , ammonium acetate , catalysis , isatin , aldehyde , cyclodextrin , ethanol , combinatorial chemistry , cascade reaction , imidazole , aqueous solution , aqueous medium , supramolecular catalysis , supramolecular chemistry , organic chemistry , reaction conditions , one pot synthesis , molecule , high performance liquid chromatography
Abstract An eco‐friendly multicomponent synthesis of substituted imidazole derivatives catalyzed by β‐cyclodextrin (β‐CD) was scrutinized for the first time via a one‐pot three‐compound reaction of aldehyde, isatin, and ammonium acetate in H 2 O–EtOH at 80°C. β‐CD is a supramolecule, highly efficient, biodegradable, and recyclable catalyst used to produce high yields of desired 1,8‐dihydroimidazo[2,3‐ b ]indoles. The developed protocol contains number of advantages like nontoxic, inexpensive catalyst; green reaction condition; easily available starting material; shorter reaction time; and good yields.