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Design, synthesis, and bioactivity of nortopsentin analogues containing 1,2,4‐triazole moieties
Author(s) -
Zhao Xinyu,
Liao Ancai,
Zhang Fan,
Zhao Qi,
Zhou Lijia,
Fan Jingjing,
Zhang Zheng,
Wang Ziwen,
Wang Qingmin
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3817
Subject(s) - fungicide , chlorothalonil , chemistry , carbendazim , antifungal , triazole , lead compound , broad spectrum , pesticide , combinatorial chemistry , ribavirin , stereochemistry , organic chemistry , botany , biochemistry , microbiology and biotechnology , biology , agronomy , in vitro , gene , genotype
Plant diseases are serious and difficult to control. Novel and efficient pesticides are urgently needed. A series of nortopsentin analogues were designed, synthesized, and evaluated for their antiviral activities and fungicidal activities. Compound 3g with higher antiviral activity than nortopsentin D and ribavirin emerged as new antiviral lead compound. Further fungicidal activity tests revealed that nortopsentin analogues displayed broad‐spectrum fungicidal activities. Compounds 3a , 3d , and 3f displayed higher antifungal activities against Cercospora arachidicola Hori than commercial fungicides carbendazim and chlorothalonil. Current research has laid a foundation for the application of nortopsentin analogues in plant protection.