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One‐pot multicomponent synthesis of a new series of curcumin‐derived 4 H ‐pyrans under ambient conditions
Author(s) -
Brahmachari Goutam,
Mandal Mullicka
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3814
Subject(s) - chemistry , malononitrile , curcumin , sodium formate , tandem , combinatorial chemistry , organic chemistry , solvent , reaction conditions , environmentally friendly , catalysis , biochemistry , materials science , composite material , ecology , biology
Design and synthesis of a new series of pharmaceutically interesting curcumin‐derived 4 H ‐pyrans have been accomplished via a one‐pot tandem reaction between curcumin, aromatic aldehydes, and malononitrile under the influence of sodium formate as a mild base in ethanol at ambient conditions. Operational simplicity, mild reaction conditions, use of a cheap and nontoxic organocatalyst and eco‐friendly solvent, and easy isolation of target products are the key benefits associated with the process.