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Synthesis of imidazole derivatives: Ester and hydrazide compounds with antioxidant activity using ionic liquid as an efficient catalyst
Author(s) -
Abdelhamid Antar A.,
Salah Hanan A.,
Marzouk Adel A.
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3808
Subject(s) - chemistry , catalysis , ionic liquid , hydrazide , moiety , imidazole , yield (engineering) , hydrochloride , antioxidant , organic chemistry , proton nmr , ammonium acetate , combinatorial chemistry , high performance liquid chromatography , materials science , metallurgy
The pyrrolidinium hydrogen sulfate (PHS) was used as an excellent ionic liquid catalyst for the preparation of many imidazoles moiety, which have biologically application via one‐pot multicomponent reaction. Imidazoles were afforded through the reaction of equimolar from 1,2‐diphenylethane‐1,2‐dione, ammonium acetate, different aromatic aldehydes, and ethyl glycinate hydrochloride. This method has the advantages of giving excellent yield, shortened reaction times, and ease of establishment. Moreover, the yielded of imidazoles components can be purified and crystallized by a nonchromatographic technique, and the catalyst can be reused. These entire novel synthesized components have been identified by spectral data: IR, NMR and mass spectra. These compounds have an in vivo antioxidant activity on experimental animals (rats).