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Synthesis and DABCO‐induced demethylation of 3‐cyano‐4‐methoxy‐2‐pyridone derivatives
Author(s) -
Li Jing,
Tan HongRu,
An YuLong,
Shao ZhiYu,
Zhao ShengYin
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3783
Subject(s) - dabco , chemistry , demethylation , 2 pyridone , yield (engineering) , combinatorial chemistry , medicinal chemistry , organic chemistry , octane , biochemistry , gene expression , materials science , metallurgy , dna methylation , gene
Abstract An efficient method for synthesis and demethylation of 3‐cyano‐4‐methoxy‐2‐pyridone derivatives has been developed. DABCO‐induced demethylation can lead to 3‐cyano‐4‐hydroxy‐2‐pyridones in DMF at 90°C with high yield. The protocol is applicable for the synthesis of 3‐cyano‐4‐hydroxy‐2‐pyridone derivatives. The method is simple, efficient, and practical.