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Synthesis of novel piperazine tethered benzocycloheptenone hybrids and their antimicrobial evaluation
Author(s) -
Naikal James Prameela Subhashini,
Jilla Lavanya,
Vanguru Sowmya
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3778
Subject(s) - piperazine , chemistry , antimicrobial , gram , proton nmr , strain (injury) , stereochemistry , in vitro , carbon 13 nmr , antibacterial activity , combinatorial chemistry , bacteria , organic chemistry , biochemistry , medicine , genetics , biology
A new series of benzosuberone‐piperazine hybrids 6a to j were designed and synthesized efficiently in good yields and their structures were confirmed by 1 H NMR, 13 C NMR, ESI‐MS and HRMS. The newly synthesized compounds were evaluated for their in vitro antimicrobial activity against Gram positive, Gram negative bacterial strains and a fungal strain. Among the synthesized compounds, compounds 6c , 6d , 6e , 6f , 6g and 6h exhibited potent antibacterial activity with MIC value of 1.9 μg/mL against Gram positive and Gram negative organisms.
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