Premium
Highlights on the synthesis of novel phenothiazine‐based azines scaffold as antioxidant agents
Author(s) -
Hamama Wafaa S.,
Gouda Moustafa A.,
Kamal Eldin Hadwah A.,
Zoorob Hanafi H.
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3771
Subject(s) - phenothiazine , chemistry , antioxidant , combinatorial chemistry , abts , reagent , bleomycin , stereochemistry , organic chemistry , pharmacology , medicine , surgery , chemotherapy , dpph
Abstract Azines derivatives of phenothiazines were synthetically constructed from one‐pot multicomponent reactions of 1‐(4a,10a‐dihydro‐10 H ‐phenothiazin‐2‐yl)ethan‐1‐one with various reagents. The obtained novel target compounds were evaluated as antioxidant agents using ABTS +• scavenging assay. Antioxidant results revealed that the incorporation of azines to phenothiazine ring system enhanced the activity. In addition, compound 18 prevent the damage of DNA due to the formation of bleomycin‐iron complex more than the standard compound.