A simple route to morpholine derivatives via copper‐acetylide addition to carbodiimide in the presence of oxiranes | Zendy

SamzadehKermani Alireza | Zendy

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A simple route to morpholine derivatives via copper‐acetylide addition to carbodiimide in the presence of oxiranes

Author(s) -

SamzadehKermani Alireza

Publication year - 2020

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.3770

Subject(s) - chemistry , morpholine , carbodiimide , regioselectivity , acetylide , anhydrous , aryl , alkyl , organic chemistry , catalysis , medicinal chemistry , combinatorial chemistry

A novel catalytic multicomponent reaction for the synthesis of morpholine derivatives has been reported. The reactions involve terminal alkynes, carbodiimides, and oxiranes using [Cu (CH 3 CN) 4 ]PF 6 , t BuOLi, and TBPAc in anhydrous NMP. Aryl and heteroaromatic terminal alkynes were tolerated. Carbodiimides could be symmetrical and unsymmetrical substrates with aryl or alkyl substituents. The reaction exhibited a good regioselectivity when unsymmetrical carbodiimides were employed.

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