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TEMPO‐catalyzed decarboxylation reactions for the synthesis of 1,2‐unsubstituted indolizines
Author(s) -
Zhang Yuxuan,
Wang Wenhui,
Sun Jinwei,
Liu Yun
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3766
Subject(s) - chemistry , decarboxylation , substituent , catalysis , combinatorial chemistry , scope (computer science) , reaction conditions , organic chemistry , computer science , programming language
Abstract An efficient synthesis of 1,2‐unsubstituted indolizines was developed via 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO)–catalyzed decarboxylation reaction. A series of target products were successfully prepared with the tolerance of a variety of functional groups. This protocol features advantages such as easily available substrates, broad substituent scope, and eco‐friendly conditions.