Synthesis of pyrazine‐2,3‐dicarbonitriles via the one‐pot three‐component reaction of 4‐benzoyl‐5‐phenylamino‐2,3‐dihydrothiophene‐2,3‐dione, diaminomaleonitrile, and functionalized alcohols in acetonitrile | Zendy

Shahnaei Roya | Zendy; Kabirifard Hassan | Zendy; Fathololoomi Parinaz | Zendy

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Synthesis of pyrazine‐2,3‐dicarbonitriles via the one‐pot three‐component reaction of 4‐benzoyl‐5‐phenylamino‐2,3‐dihydrothiophene‐2,3‐dione, diaminomaleonitrile, and functionalized alcohols in acetonitrile

Author(s) -

Shahnaei Roya,

Kabirifard Hassan,

Fathololoomi Parinaz

Publication year - 2020

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.3761

Subject(s) - chemistry , acetonitrile , pyrazine , solvent , medicinal chemistry , alkoxy group , component (thermodynamics) , methanol , organic chemistry , alkyl , physics , thermodynamics

An efficient one‐pot three‐component reaction of 4‐benzoyl‐5‐phenylamino‐2,3‐dihydrothiophene‐2,3‐dione, diaminomaleonitrile, and alcohols with hetero‐atom substituents or several hydroxyl groups in acetonitrile solvent under reflux led to the formation of 5‐(2‐substituted ethoxy or propoxy‐2‐phenyl‐1‐ N ‐phenylthiocarbamoylethenyl)‐6‐oxo‐1,6‐dihydropyrazine‐2,3‐dicarbonitrile derivatives in good yields.

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