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Synthesis of pyrazine‐2,3‐dicarbonitriles via the one‐pot three‐component reaction of 4‐benzoyl‐5‐phenylamino‐2,3‐dihydrothiophene‐2,3‐dione, diaminomaleonitrile, and functionalized alcohols in acetonitrile
Author(s) -
Shahnaei Roya,
Kabirifard Hassan,
Fathololoomi Parinaz
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3761
Subject(s) - chemistry , acetonitrile , pyrazine , solvent , medicinal chemistry , alkoxy group , component (thermodynamics) , methanol , organic chemistry , alkyl , physics , thermodynamics
An efficient one‐pot three‐component reaction of 4‐benzoyl‐5‐phenylamino‐2,3‐dihydrothiophene‐2,3‐dione, diaminomaleonitrile, and alcohols with hetero‐atom substituents or several hydroxyl groups in acetonitrile solvent under reflux led to the formation of 5‐(2‐substituted ethoxy or propoxy‐2‐phenyl‐1‐ N ‐phenylthiocarbamoylethenyl)‐6‐oxo‐1,6‐dihydropyrazine‐2,3‐dicarbonitrile derivatives in good yields.