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Ultrasound‐assisted synthesis of novel spiro[indoline‐3,5′‐pyrido[2,3‐ d ]pyrimidine] derivatives using Fe 3 O 4 @Propylsilane@Histidine[HSO 4 − ] as an effective magnetic nanocatalyst
Author(s) -
Mousavifar Seyyedeh Masoumeh,
Kefayati Hassan,
Shariati Shahab
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3758
Subject(s) - chemistry , isatin , pyrimidine , indoline , yield (engineering) , catalysis , acetylene , histidine , condensation , organic chemistry , medicinal chemistry , combinatorial chemistry , stereochemistry , materials science , physics , metallurgy , thermodynamics , enzyme
A simple, economical, three‐component, and one‐pot synthesis of novels spiro[indoline‐3,5′‐pyrido[2,3‐ d ]pyrimidine] derivatives by condensation of dimethyl acetylene dicarboxylate, isatin derivatives, and 6‐amino‐1,3‐dimethyluracil in presence of Fe 3 O 4 @Propylsilane@Histidine[HSO 4 − ] as an impressive catalyst via reflux and ultrasound procedure is described. The results show that ultrasound method has several advantages such as milder condition, shorter reaction time, and higher reaction yield.

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