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Preparation of novel azidopyrazole derivatives with anticipated cytotoxic and antimicrobial activities
Author(s) -
Ewies Ewies F.,
ElHussieny Marwa,
ElSayed Naglaa F.,
ElShazly Mohamed,
Chen YuCheng,
Liu YiChang
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3747
Subject(s) - chemistry , antimicrobial , methylene , cytotoxic t cell , combinatorial chemistry , primary (astronomy) , organic chemistry , biochemistry , in vitro , physics , astronomy
The reactions of azidopyrazole with some of primary amines and active methylene compounds were studied. Structures of the prepared compounds were identified using spectroscopic techniques. The reactions mechanisms were also proposed. The cytotoxic and antimicrobial activities were also examined for the newly synthesized compounds.