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Synthesis of imidazo[1, 2‐a]pyridines via the silver acetate‐catalyzed Groebke‐Blackburn‐Bienayme reaction with ethylene glycol as a biodegradable and sustainable solvent
Author(s) -
Hussain Mustafa,
Liu Jianhui,
Fu Lu,
Hasan Mehdi
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3746
Subject(s) - chemistry , ethylene glycol , catalysis , environmentally friendly , solvent , aryl , organic chemistry , ethylene , ethyl acetate , ecology , alkyl , biology
An efficient, silver‐based catalytic system has been designed for the synthesis of biologically important 3‐aminoimidazo‐fused heterocycles via the Groebke‐Blackburn‐Bienayme reaction, in which AgOAc was used as a catalyst and ethylene glycol as a solvent from isocyanides, various aryl aldehydes and an 2‐amino heterocycle were also used. Good to excellent yields, high atomic economy and environmentally friendly conditions are the potential features of this one‐pot process.