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Synthesis of some novel pyrazolopyrimidotriazepine, pyrazolotriazolopyrimidine, and pyrazolopyrimidotetrazine derivatives
Author(s) -
Hassan Aisha Y.,
AbdelAziem Anhar,
Hussain Aisha O.
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3744
Subject(s) - chemistry , elemental analysis , pyrimidine , carboxylate , mass spectrum , pyrazole , proton nmr , medicinal chemistry , nmr spectra database , stereochemistry , combinatorial chemistry , organic chemistry , spectral line , ion , physics , astronomy
Abstract Reaction of ethyl 5‐amino‐1‐phenyl‐1 H ‐pyrazole‐4‐carboxylate with thiocarbohydrazide yielded 5‐amino‐6‐hydrazinyl‐1‐phenyl‐1 H ‐pyrazolo[3,4‐ d ]pyrimidine‐4‐(5 H )one ( 1 ), which used as precursor to synthesize pyrazolopyrimidotriazepine 2 , pyrazolopyrimidotriazines 5‐7 , pyrazolotriazolopyrimidines 8 ‐ 14 , pyrazolopyrimidotetrazines 17 . The structures of the newly synthesized compounds were confirmed by spectral data (IR, NMR, elemental analysis, and mass spectra).