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One‐pot three‐component synthesis of chromeno [2,3‐ d ] pyrimidine derivatives: Novel, simple, and efficient electrochemical approach
Author(s) -
Malviya Jyoti,
Singh Rana Krishna Pal
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3741
Subject(s) - chemistry , pyrimidine , barbituric acid , ammonium iodide , yield (engineering) , combinatorial chemistry , electrochemistry , organic chemistry , stereochemistry , materials science , electrode , metallurgy
An atom economical, selective, and convenient one‐pot protocol for the synthesis of the medicinally privileged novel chromeno [2,3‐ d ] pyrimidine scaffold, viz, multicomponent reaction of barbituric acid derivatives, 1,3 cyclic diketone, and various aldehydes in the presence of tetra n ‐butyl ammonium iodide (TBAI) as an electrolyte in water media under room temperature, is reported. This ecologically sound novel concept offers environmentally benign synthetic route, short reaction times, and easy workup procedure with excellent yield (88% to 90%) and is also beneficial for diversity‐oriented large‐scale processes. The synthesized products were characterized by IR, MS, NMR, and CHN analysis.