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Lewis acid–catalyzed green synthesis and biological studies of pyrrolo[3,4‐ c ]pyrazoles in aqueous medium
Author(s) -
Kaur Manpreet,
Singh Baldev,
Arjuna Anania
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3740
Subject(s) - chemistry , lewis acids and bases , catalysis , aqueous medium , aqueous solution , lewis acid catalysis , pyrazoline , solvent , organic chemistry , cycloaddition , green chemistry , maleimide , combinatorial chemistry , reaction mechanism
An environmentally benign approach in aqueous medium by means of Lewis acid catalyst affords a wide spectrum of pyrazoline derivatives in satisfactory yields. [3+2] cycloaddition reactions of substituted azomethine‐ N ‐imines to maleimide in aqueous medium at relatively high concentrations of Lewis acid catalyst have emerged as an environment friendly alternative to conventional solvents. Promising catalytic activity has been revealed by Lewis acid like Cu (NO 3 ) 2 in aqueous medium. The obvious features of this synthetic protocol were short reaction time, high efficiency, less hazardous synthesis by benign solvent, catalysis, modest workup, and a clean reaction methodology.