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Synthesis of novel hexahydroquinolines and 6‐amino‐2‐oxopyridine‐3,5‐dicarbonitriles incorporating sulfamethoxazole via [3 + 3] annulation
Author(s) -
Abdelmoniem Amr M.,
Abdelrahman Mohamed Gamal Mohamed,
Ghozlan Said Ahmed Soliman,
Abdelhamid Ismail A.
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3737
Subject(s) - chemistry , annulation , piperidine , moiety , cyanoacetamide , pyridine , sulfamethoxazole , derivative (finance) , combinatorial chemistry , organic chemistry , medicinal chemistry , catalysis , antibiotics , biochemistry , financial economics , economics
Cyclic enaminone and cyanoacetamide derivative with incorporated sulfamethoxazole moiety were prepared. Their reactions with arylidenemalononitrile derivatives in ethanol or pyridine/piperidine at reflux yielded the corresponding hexahydroquinoline and 6‐amino‐2‐oxopyridine‐3,5‐dicarbonitrile derivatives incorporating sulfamethoxazole. The mechanism and structural elucidation of products were discussed.