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Exploiting silver trifluoromethanesulfonate as efficient and reusable catalyst for the synthesis of dihydropyrimidine derivatives under different reaction environments
Author(s) -
Roy Dipak Kumar,
Tamuli Kashyap Jyoti,
Bordoloi Manobjyoti
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3728
Subject(s) - chemistry , trifluoromethanesulfonate , catalysis , acetonitrile , microwave irradiation , solvent , reaction conditions , combinatorial chemistry , organic chemistry
Different results were generated under different reaction conditions for the multicomponent reactions. Herein, an efficiently improved and mild protocol for the synthesis of dihydropyrimidine derivatives using cheap silver trifluoromethanesulfonate (CF 3 SO 3 Ag) as reusable catalyst is explained. With conventional heating and microwave irradiation method, the synthesis of substituted 3,4‐dihydropyrimidine‐2(1 H )‐one and 3,4‐dihydropyrimidine‐2(1 H )‐thione was achieved in different solvent environments like acetonitrile, water, and under solvent free neat condition. Moreover, the solvents (CH 3 CN and H 2 O) containing the CF 3 SO 3 Ag were reused for several times without loss of much catalytic activity after separation from the desired products. Thus, the method provides much improved and efficient alternative pathway to the original Biginelli reaction.