Premium
Green approach for the synthesis of 3‐methyl‐1‐phenyl‐4‐((2‐phenyl‐1H‐indol 3‐yl)methylene)‐1H‐pyrazole‐5(4H)‐ones and their DNA Cleavage, antioxidant, and antimicrobial activities
Author(s) -
Modi Madhuri,
Jain Meenakshi
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3726
Subject(s) - chemistry , methylene , antimicrobial , proton nmr , yield (engineering) , pyrazole , carbon 13 nmr , elemental analysis , organic chemistry , medicinal chemistry , condensation reaction , catalysis , materials science , metallurgy
3‐Methyl‐1‐phenyl‐4‐((2‐phenyl‐1 H ‐indol‐3‐yl)methylene)‐1 H ‐pyrazol‐5(4H)‐ones (5a‐i) was prepared by the condensation reaction of different 3‐formyl‐2‐phenylindole derivatives (2a‐i) and 3‐methyl‐1‐phenyl‐2‐pyrazoline‐5‐one in quantitative yield by applying various green synthetic methods as grinding, microwave irradiation using different catalysts under solvent‐free mild reaction conditions with high product yields. The structures of the synthesized compounds were characterized on the basis of elemental analysis, infrared, 1 HNMR, 13 C NMR, and mass spectral data. The synthesized compounds were screened for free radical scavenging, antimicrobial, and DNA cleavage activities. Most of the tested compounds belonging to the 3‐methyl‐1‐phenyl‐4‐((2‐phenyl‐1 H ‐indol‐3‐yl)methylene)‐1 H ‐pyrazol‐5(4H)‐ones series exhibited promising activities.