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NO 2 ‐Fe (II)Pc‐catalyzed synthesis of 2‐ferrocenyl‐5‐aryl‐1,3,4‐oxadiazoles and study of antifungal activity
Author(s) -
Ge Man,
Feng Jie,
Huang Hailian,
Gou Xiaofeng,
Hua Chengwen,
Chen Bang,
Zhao Junlong
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3725
Subject(s) - chemistry , antifungal , catalysis , aryl , mass spectrometry , infrared spectroscopy , single crystal , medicinal chemistry , crystal structure , high resolution , organic chemistry , nuclear chemistry , crystallography , medicine , alkyl , chromatography , dermatology , remote sensing , geology
Abstract Six novel derivatives of 2‐ferrocenyl‐5‐aryl‐1,3,4‐oxadiazoles have been synthesized through catalytic oxidation of benzoylhydrazone with nitrophthalocyanine iron (II) as catalyst and tert‐butyl hydroperoxide as oxidant. All of the compounds have been characterized by high‐resolution mass spectrometry, 1 H, 13 C NMR, and infrared spectroscopy. Moreover, the antifungal activities of all new compounds have been evaluated and the results showed that the compounds exhibited excellent antifungal activities. In addition, the molecular structure of compound 1c could also be determined by X‐ray single‐crystal diffraction.