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A highly efficient methodology for 5‐methyl‐3‐aryl‐2‐thiooxazolidin‐4‐ones using lithium perchlorate in DIPEA mediated synthesis
Author(s) -
Khatik Gopal L.,
Pal Anang,
Apsunde Tushar D.,
Nair Vipin A.
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.369
Subject(s) - chemistry , aryl , lithium perchlorate , lithium (medication) , combinatorial chemistry , catalysis , organic chemistry , alkyl , medicine , electrode , electrochemistry , endocrinology
An efficient methodology for the synthesis of 5‐methyl‐3‐aryl‐2‐thiooxazolidin‐4‐ones from aryl isothiocyanates has been developed. Aryl isothiocyanates, synthesized from various anilines, were converted to the desired compounds by treating with ethyl lactate in presence of DIPEA and catalytic amount of lithium perchlorate. This method provides a convenient and cost‐effective strategy, with no specific purification protocol. J. Heterocyclic Chem., (2010).