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Organocatalytic Green Approach Towards the Fabrication of Fused Benzo N , N ‐containing Heterocycles Facilitated by Ultrasonic Irradiation
Author(s) -
grum Ridaphun,
Kharmawlong George Kupar,
Rani Jims World Star,
Rahman Noimur,
Dutta Arup,
gkhlaw Rishanlang
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3680
Subject(s) - chemistry , regioselectivity , combinatorial chemistry , benzimidazole , green chemistry , reaction conditions , organic chemistry , catalysis , reaction mechanism
The development of a metal‐free protocol for transformations in organic synthesis offers a significant potential environmental benefit. This article reports the exploration of meglumine, a nontoxic and biodegradable amino sugar, as an organocatalyst for the synthesis of biologically active 1 H ‐dibenzo[ b , e ][1,4]diazepin‐1‐ones, highly regioselective benzimidazole derivatives and derivatives of quinoxalines. Operational simplicity, mild reaction conditions, shorter reaction times, and use of green solvents are the highlights of this protocol. The advantage of ultrasonic irradiation has been significantly explored for the synthesis of the aforesaid compounds. Furthermore, the multifaceted use of o ‐phenylenediamine has also been accentuated in the study.