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Green Synthesis of Imidazole Derivatives via Fe 3 O 4 ‐MNPs as Reusable Catalyst
Author(s) -
Shafaei Faezeh,
Sharafian Shirin
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3678
Subject(s) - chemistry , imidazole , catalysis , isothiocyanate , triphenylphosphine , green chemistry , combinatorial chemistry , ferric , solvent , chloride , alkyl , magnetic nanoparticles , nanoparticle , organic chemistry , iron oxide nanoparticles , iron oxide , nanotechnology , reaction mechanism , materials science
In this research, a one‐pot, efficient, and high yielding procedure for the synthesis of imidazole derivatives is investigated. The procedure was carried out via multicomponent reaction of isothiocyanate, alkyl bromides, N ‐methylimidazole, and triphenylphosphine in the presence of magnetic iron oxide nanoparticles (Fe 3 O 4 ‐MNPs) as reusable catalyst under solvent‐free conditions at 50°C. Also, Fe 3 O 4 ‐MNPs were produced using green synthetic method by reduction of ferric chloride solution with Clover Leaf water extract. The nanoparticles generated using this procedure can potentially be important in different purposes such as organic synthesis. Easy, simple, rapid, and clean procedures for the synthesis of imidazole derivatives are the advantages of this study.